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Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections

Abstract : Human Papillomaviruses (HPV) are one of the most prevalent sexually transmitted infections (STI) and the most oncogenic viruses known to humans. The vast majority of HPV infections clear in less than 3 years, but the underlying mechanisms, especially the involvement of the immune response, are still poorly known. Building on earlier work stressing the importance of randomness in the type of cell divisions in the clearance of HPV infection, we develop a stochastic mathematical model of HPV dynamics that combines the previous aspect with an explicit description of the intracellular level. We show that the random partitioning of virus episomes upon stem cell division and the occurrence of symmetric divisions dramatically affect viral persistence. These results call for more detailed within-host studies to better understand the relative importance of stochasticity and immunity in HPV infection clearance.
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https://hal.archives-ouvertes.fr/hal-03357550
Contributor : Samuel Alizon Connect in order to contact the contributor
Submitted on : Tuesday, September 28, 2021 - 8:36:57 PM
Last modification on : Friday, August 5, 2022 - 10:43:01 AM
Long-term archiving on: : Wednesday, December 29, 2021 - 7:38:33 PM

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Thomas Beneteau, Christian Selinger, Mircea T Sofonea, Samuel Alizon. Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections. PLoS Computational Biology, Public Library of Science, 2021, 17 (9), pp.e1009352. ⟨10.1371/journal.pcbi.1009352⟩. ⟨hal-03357550⟩

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