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Cell motility in confinement: a computational model for the shape of the cell

Abstract : While cells typically tend to spread their cytoplasm in a flat and thin lamellipodium when moving on a flat substrate, it is widely observed that the cytoplasm has a compact shape in micro-channels, tending to fulfill the cross-section of the microchannel. We propose a minimal mathematical model for a 2D test case which describes the cell lamellipodium deformations when confined in a channel. We then go through a numerical investigation of this mathematical model and show that it allows to recover qualitatively the physiological characteristics of the confined cell.
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https://hal.archives-ouvertes.fr/hal-03352663
Contributor : Florence HUBERT Connect in order to contact the contributor
Submitted on : Friday, September 24, 2021 - 9:43:58 AM
Last modification on : Thursday, September 1, 2022 - 11:08:46 AM

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Florence Hubert, Meriem Jedouaa, Imene Khames, Julien Olivier, Olivier Theodoly, et al.. Cell motility in confinement: a computational model for the shape of the cell. ESAIM: Proceedings and Surveys, EDP Sciences, 2016, 55, pp.148-166. ⟨10.1051/proc/201655166⟩. ⟨hal-03352663⟩

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