Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines

Sarwar Beg , Waleed Almalki , Fahmida Khatoon , Khalid Alharbi , Saad Alghamdi (1) , Md. Habban Akhter , Habibullah Khalilullah , Abdullah Baothman , Abdul Hafeez , Mahfoozur Rahman , Sohail Akhter (2) , Hani Choudhry

1 King Abdullah Univ Sci & Technol, Phys Sci & Engn Div, Thuwal 23955, Makkah, Saudi Arabia
2 CBM - Centre de biophysique moléculaire

Cancer vaccines consist of nucleic acid derivatives such as plasmid DNA, small interfering RNA and mRNA, and can be customized according to the patient's needs. Nanomedicines have proven to be exceptionally good as miniaturized drug carriers, and thus they offer great advantages for delivering cancer vaccines. This review provides an overview of the literature on cancer vaccines, from their inception to current developments in the field.

Domaines: Sciences du Vivant [q-bio]

Sarwar Beg, Waleed Almalki, Fahmida Khatoon, Khalid Alharbi, Saad Alghamdi, et al.. Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines. Drug Discovery Today, 2021, 26 (8), pp.1891-1903. ⟨10.1016/j.drudis.2021.02.013⟩. ⟨hal-03348995⟩