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How can polyreactive antibodies conquer rapidly evolving viruses?

Abstract : Broadly neutralizing antibodies against rapidly-evolving viruses (e.g. HIV-1 and influenza virus), often manifest antigen-binding promiscuity. Based on a recent study, we hypothesize on the significance of antibody polyreactivity in neutralization of rapidly-evolving viruses. We propose that polyreactivity contributes to tolerate viral variants and shortens time for appearance of neutralizing antibodies.
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https://hal.sorbonne-universite.fr/hal-03344263
Contributor : Dimitrov Jordan <>
Submitted on : Tuesday, September 14, 2021 - 6:30:51 PM
Last modification on : Thursday, September 16, 2021 - 3:12:35 AM

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Alejandra Reyes-Ruiz, Jordan Dimitrov. How can polyreactive antibodies conquer rapidly evolving viruses?. Trends in Immunology, Elsevier, 2021, 42 (8), pp.654-657. ⟨10.1016/j.it.2021.06.008⟩. ⟨hal-03344263⟩

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