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New perspectives on the calculation of bioaccumulation metrics for active substances in living organisms

Abstract : Today, only few ready-to-use and convenient decision-making tools are available in ecotoxicology concerning accumulation and effects of chemical substances on organisms, accounting for exposure situations that are known to be complex (routes of exposure, metabolism, mixtures, etc.). This paper presents new perspectives on the generic calculation of bioaccumulation metrics via the innovative web tool MOSAICbioacc (http://mosaic.univ-lyon1.fr/bioacc). MOSAICbioacc provides all kinds of bioaccumulation metrics associated with their uncertainty whatever the species-compound combination. MOSAICbioacc expects accumulation-depuration data as inputs, even with complex exposure and clearance patterns, to quickly perform their relevant analysis. MOSAICbioacc intends to facilitate the daily work of regulators, or any ecotoxicologist, who will freely benefit from a user-friendly online interface that automatically fits toxicokinetic models without need for users to invest in the technical aspects to get bioaccumulation metrics estimates. MOSAICbioacc also provides all results in a fully transparent way to ensure reproducibility
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https://hal.archives-ouvertes.fr/hal-03343427
Contributor : Christelle Lopes Connect in order to contact the contributor
Submitted on : Tuesday, September 14, 2021 - 10:39:22 AM
Last modification on : Saturday, September 24, 2022 - 2:36:04 PM

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Aude Ratier, Gauthier Multari, Vanessa Mazerolles, Patrice Carpentier, Sandrine Charles, et al.. New perspectives on the calculation of bioaccumulation metrics for active substances in living organisms. Integrated Environmental Assessment and Management, Wiley, 2022, 18 (1), pp.10-18. ⟨10.1002/ieam.4439⟩. ⟨hal-03343427⟩

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