Protein disorder in algal metabolism

Hélène Launay (1) , Veronique Receveur-Brechot (1) , Frédéric Carrière (1) , Brigitte Gontero (1)

1 BIP - Bioénergétique et Ingénierie des Protéines

Intrinsically disordered proteins (IDPs) or proteins with intrinsically disordered regions (IDRs) are peculiar proteins that escape from the classic structure-function paradigm. The principal feature of these IDPs/IDRs containing proteins is the absence of a unique stable conformation which results in a high structural flexibility or plasticity. Their other features are their ability to bind to many partners, their numerous functions and their resistance to a wide range of physicochemical conditions. Because of this plasticity, IDPs/IDRs containing proteins are advantageous for algae that can cope with extreme conditions of pH, temperature, pressure and light. To survive to such a wide range of conditions, metabolic regulation is essential. IDPs and IDRs containing protein are heavily involved in the metabolic regulation, but have been overlooked in photosynthetic algae, in contrast to other kingdoms of Life.

Domaines: Biochimie [q-bio.BM]

Hélène Launay, Veronique Receveur-Brechot, Frédéric Carrière, Brigitte Gontero. Protein disorder in algal metabolism. 2021. ⟨hal-03326941⟩