Pyridazino-1,3a,6a-triazapentalenes as versatile fluorescent probes: Impact of their post-functionalization and application for cellular imaging

Doina Sirbu (1) , Nicolas Chopin (1) , Ivana Martinić (2) , Moussa Ndiaye (1) , Svetlana V. Eliseeva (2) , Marie-Aude Hiebel (1) , Stephane Petoud (2) , Franck Suzenet (1)

1 ICOA - Institut de Chimie Organique et Analytique
2 CBM - Centre de biophysique moléculaire

Pyridazino-1,3a,6a-triazapentalenes (PyTAP) are compact fused 6/5/5 tricyclic scaffolds which exhibit promising fluorescent properties. Chemically stable, they can be post-functionalized using standard Pd-catalyzed cross-coupling chemistry. Several original PyTAP bearing additional unsaturated substituents in positions 2 and 8 were synthetized and their spectroscopic properties analyzed. They have been successfully tested as fluorescent probes for cellular imaging.

Mots clés: pyridazino-1 -1; 3a; 6a-triazapentalenes; fluorophores; photostability; cell imaging; fluorescence

Domaines: Sciences du Vivant [q-bio]

Doina Sirbu, Nicolas Chopin, Ivana Martinić, Moussa Ndiaye, Svetlana V. Eliseeva, et al.. Pyridazino-1,3a,6a-triazapentalenes as versatile fluorescent probes: Impact of their post-functionalization and application for cellular imaging. International Journal of Molecular Sciences, 2021, 22 (12), pp.6645. ⟨10.3390/ijms22126645⟩. ⟨hal-03325350⟩