The Alternative Sigma Factor SigB Is Required for the Pathogenicity of Bacillus thuringiensis
Résumé
Pathogenic bacteria often need to transition between different ecosystems, and their ability to cope with such variations is critical for their survival. Several Gram-positive species have developed an adaptive response mediated by the general stress response alternative sigma factor SigB. In order to understand the ecophysiological role of this regulator in Bacillus thuringiensis , an entomopathogenic bacterium widely used as a biopesticide, we sought to examine the fate of a Δ sigB mutant during its life cycle in the natural setting of an insect larva. This allowed us, in particular, to show that SigB was activated during infection and that it was required for the pathogenicity of B. thuringiensis via the oral route of infection.
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