Sleep changes induced by the local application of 5,7-dihydroxytryptamine into the nodose ganglia and aortic denervation in the rat

Hakan S. Orer (1) , Nacera Merahi (1) , Anne Nosjean (1) , Henri Gozlan (1) , Raul Laguzzi (1)

1 Neuropsychopharmacologie moléculaire, cellulaire et fonctionnelle

The effects of a bilateral microinjection of 5,7-dihydroxytryptamine (5,7-DHT) into the nodose ganglia and aortic denervation on the daily amounts of sleep/wake states were studied in rats. Both lesions produced an increase in paradoxical sleep and provoked the onset of paradoxical sleep episodes without slow-wave-sleep transition ("narcolepsy-like" paradoxical sleep episodes). The increase in paradoxical sleep observed after 5,7-DHT injection was more important than that of the aortic denervation. In addition, both 5,7-DHT-treated and aortic-denervated animals exhibited a delayed decrease in slow-wave sleep associated with an increase in wakefulness. These results show that the peripheral messages coming from aortic serotonergic afferent fibres to the nucleus tractus solitarius play a modulatory role in the daily expression of paradoxical sleep in rats.

Domaines: Neurobiologie; Psychologie et comportements; Sciences cognitives

Hakan S. Orer, Nacera Merahi, Anne Nosjean, Henri Gozlan, Raul Laguzzi. Sleep changes induced by the local application of 5,7-dihydroxytryptamine into the nodose ganglia and aortic denervation in the rat. Pflügers Archiv European Journal of Physiology, 1991, 419 (1), pp.21-24. ⟨10.1007/BF00373742⟩. ⟨hal-03301167⟩