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Article Dans Une Revue ChemistrySelect Année : 2017

Screening of Activation Tools to Design Sulfated Saccharides

Résumé

O-Sulfonation of saccharides using thermal, microwave and flow chemistry activation modes is described. To this end, we studied the exhaustive monosulfation at position 4 and disulfation at positions 4,6 of several monosaccharides bearing a large variety of protecting groups. Additionally the regioselective 6-O sulfonation of 4,6-diol was explored. It is demonstrated that microwave and flow chemistry activation provide significant benefits compared to classical thermal O-sulfonation, drastically reducing the reaction time and/or the amount of sulfating reagent. To prove the versatility of the strategy, one example of 6-O-sulfonation of a disaccharide is also reported.

Domaines

Chimie organique
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Dates et versions

hal-03283191 , version 1 (09-07-2021)

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Hélène Ledru, Joseph d'Attoma, Stéphane Bostyn, Sylvain Routier, Frédéric Buron, et al.. Screening of Activation Tools to Design Sulfated Saccharides. ChemistrySelect, 2017, 2 (30), pp.9637-9641. ⟨10.1002/slct.201701853⟩. ⟨hal-03283191⟩
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