Endothelial Cell Responses to a Highly Deformable Titanium Alloy Designed for Vascular Stent Applications

Raluca Ion (1) , Gaetan Cabon (2) , Doina-Margareta Gordin (2) , Elena Ionica (1) , Thierry Gloriant (2) , Anisoara Cimpean (1)

1 UniBuc - University of Bucharest
2 ISCR - Institut des Sciences Chimiques de Rennes

Titanium alloys are widely used for biomedical applications due to their good biocompatibility. Nevertheless, they cannot be used for balloon expandable stents due to a lack of ductility compared to cobalt-chromium (Co-Cr) alloys and stainless steels. In this study, a new highly deformable Ti-16Nb-8Mo alloy was designed for such an application. However, the biological performance of a stent material is strongly influenced by the effect exerted on the behavior of endothelial cells. Therefore, the cellular responses of human umbilical vein endothelial cells (HUVECs), including morphological characteristics, cell viability and proliferation, and functional markers expression, were investigated to evaluate the biocompatibility of the alloy in the present study. The in vitro results demonstrated the suitability of this alloy for use as endovascular stents.

Mots clés: titanium alloy; in-vitro biocompatibility; endothelial cells; vascular stents

Domaines: Chimie

Raluca Ion, Gaetan Cabon, Doina-Margareta Gordin, Elena Ionica, Thierry Gloriant, et al.. Endothelial Cell Responses to a Highly Deformable Titanium Alloy Designed for Vascular Stent Applications. Journal of Functional Biomaterials, 2021, 12 (2), pp.33. ⟨10.3390/jfb12020033⟩. ⟨hal-03281464⟩