Interference of blood-coagulation vitamin K-dependent proteins in the activation of human protein C. Involvement of the 4-carboxyglutamic acid domain in two distinct interactions with the thrombin-thrombomodulin complex and with phospholipids.

Jm Freyssinet , Alain Beretz (1) , C Klein-Soyer , J Gauchy , S Schuhler , Jean-Pierre Cazenave (2)

1 Université Louis Pasteur - Strasbourg I
2 LABM - Laboratoire d'Analyses de Biologie Médicale

Domaines: Sciences pharmaceutiques

Jm Freyssinet, Alain Beretz, C Klein-Soyer, J Gauchy, S Schuhler, et al.. Interference of blood-coagulation vitamin K-dependent proteins in the activation of human protein C. Involvement of the 4-carboxyglutamic acid domain in two distinct interactions with the thrombin-thrombomodulin complex and with phospholipids.. Biochemical Journal, 1988, ⟨10.1042/bj2560501⟩. ⟨hal-03257428⟩