Efficient Access to Arylated Aza‐ullazines by Regioselective Functionalization of their pyridine ring by H‐Li exchange and Electrophilic Substitution.

Dhuaou Ibrahim (1) , Pascal Boulet (2) , Philippe Gros (1) , Philippe Pierrat (1)

1 L2CM - Laboratoire Lorrain de Chimie Moléculaire
2 IJL - Institut Jean Lamour

The regioselective functionalization of aza-ullazines has been successfully realized for the first time by either metalation using BuLi-containing aggregates (BuLi-LiDMAE) or electrophilic substitution. Mono and di-bromo-derivatives were obtained in good to excellent yields and further successfully converted into aryl and alkynyl azaullazine derivatives via Suzuki and Sonogashira crosscoupling reactions.

Domaines: Chimie organique; Catalyse

Dhuaou Ibrahim, Pascal Boulet, Philippe Gros, Philippe Pierrat. Efficient Access to Arylated Aza‐ullazines by Regioselective Functionalization of their pyridine ring by H‐Li exchange and Electrophilic Substitution.. European Journal of Organic Chemistry, 2021, 2021 (22), pp.3331-3339. ⟨10.1002/ejoc.202100333⟩. ⟨hal-03246746⟩