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Efficient Access to Arylated Aza‐ullazines by Regioselective Functionalization of their pyridine ring by H‐Li exchange and Electrophilic Substitution.

Abstract : The regioselective functionalization of aza-ullazines has been successfully realized for the first time by either metalation using BuLi-containing aggregates (BuLi-LiDMAE) or electrophilic substitution. Mono and di-bromo-derivatives were obtained in good to excellent yields and further successfully converted into aryl and alkynyl azaullazine derivatives via Suzuki and Sonogashira crosscoupling reactions.
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https://hal.archives-ouvertes.fr/hal-03246746
Contributor : Philippe Pierrat Connect in order to contact the contributor
Submitted on : Tuesday, October 5, 2021 - 9:38:30 AM
Last modification on : Tuesday, January 4, 2022 - 6:30:46 AM
Long-term archiving on: : Thursday, January 6, 2022 - 6:12:16 PM

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Dhuaou Ibrahim, Pascal Boulet, Philippe Gros, Philippe Pierrat. Efficient Access to Arylated Aza‐ullazines by Regioselective Functionalization of their pyridine ring by H‐Li exchange and Electrophilic Substitution.. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2021, 2021 (22), pp.3331-3339. ⟨10.1002/ejoc.202100333⟩. ⟨hal-03246746⟩

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