No more hypoglycaemia on days with physical activity and unrestricted diet when using a closed‐loop system for 12 weeks: A post‐hoc secondary analysis of the multicentre randomized controlled Diabeloop WP7 trial

Sylvia Franc; Pierre‐yves Benhamou; Sophie Borot; Lucy Chaillous; Brigitte Delemer; Maeva Doron; Bruno Guerci; Hélène Hanaire; Erik Huneker; Nathalie Jeandidier; Coralie Amadou; Eric Renard; Yves Reznik; Pauline Schaepelynck; Chantal Simon; Charles Thivolet; Claire Thomas; Patrick Hannaert; Guillaume Charpentier

doi:10.1111/dom.14442

Journal articles

No more hypoglycaemia on days with physical activity and unrestricted diet when using a closed‐loop system for 12 weeks: A post‐hoc secondary analysis of the multicentre randomized controlled Diabeloop WP7 trial

Sylvia Franc ^{1, 2, 3} Pierre‐yves Benhamou ⁴ Sophie Borot ⁵ Lucy Chaillous ⁶ Brigitte Delemer ⁷ Maeva Doron ⁸ Bruno Guerci ⁹ Hélène Hanaire ¹⁰ Erik Huneker ¹¹ Nathalie Jeandidier ¹² Coralie Amadou ^{1, 13} Eric Renard ^{14, 15} Yves Reznik ¹⁶ Pauline Schaepelynck ¹⁷ Chantal Simon ¹⁸ Charles Thivolet ¹⁸ Claire Thomas ² Patrick Hannaert ¹⁹ Guillaume Charpentier ^{2, 3}

1 Centre Hospitalier Sud Francilien

2 LBEPS - Laboratoire de Biologie de l'Exercice pour la Performance et la Santé

3 CERITD - Centre d'Etudes et de Recherches pour l'Intensification du Traitement du Diabète

4 CHU - Centre Hospitalier Universitaire [Grenoble]

5 Service d'Hépatologie, Hôpital Jean Minjoz, Centre Hospitalier Universitaire de Besançon, Université de Franche Comté

6 CHU Nantes - Centre hospitalier universitaire de Nantes

7 Service d'Endocrinologie - Diabète - Nutrition [Reims]

8 CEA-LETI - Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information

9 UL - Université de Lorraine

10 Service de Diabétologie - Maladies Métaboliques - Nutrition

11 DIABELOOP S.A.

12 CHU Strasbourg

13 UP11 - Université Paris-Sud - Paris 11

14 IGF - Institut de Génomique Fonctionnelle

15 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

16 Hôpital Côte de Nacre [CHU Caen]

17 CHU Marseille

18 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]

19 IRTOMIT - Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques

Abstract : Objective: To investigate the efficacy of the Diabeloop Generation-1 (DBLG1) closed-loop system to control the hypoglycaemia induced by physical activity (PA) in real-life conditions. Methods: This was a post-hoc analysis of the Diabeloop WP7 multicentre randomized controlled trial. Glycaemic outcomes were compared between days with and without PA in 56 patients with type 1 diabetes (T1D) using DBLG1 for 12 weeks. After the patient announces a PA, DBLG1 reduces insulin delivery and, if necessary, calculates the amount of preventive carbohydrates (CHO). Results: Daily time spent in the interstitial glucose range <70 mg/dL was not significantly different between days with and without PA (2.0 ± 1.5% versus 2.2 ± 1.1%) and this regardless of the intensity or duration of the PA. Preventive CHO intake recommended by the system was significantly higher in days with PA (41.1 ± 35.5 versus 21.8 ± 28.5 g/day; P <0.0001), and insulin delivery was significantly lower (31.5 ± 10.5 versus 34.0 ± 10.5 U/day; P <0.0001). The time spent in hyperglycaemia and the glycaemic variation coefficient increased significantly on days with PA. Conclusions: In real-life conditions, the use of DBLG1 avoids PA-induced hypoglycaemia. Insulin adjustments and preventive CHO recommendation may explain this therapeutic benefit.

Keywords : Artificial pancreas closed-loop system continuous glucose monitoring glycaemic control hypoglycaemia insulin pump therapy physical activity physical intervention randomized controlled trial type 1 diabetes

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Journal articles

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Life Sciences [q-bio]

Life Sciences [q-bio] / Human health and pathology

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https://hal.archives-ouvertes.fr/hal-03240584
Contributor : Nathalie C. Guerineau <>
Submitted on : Friday, May 28, 2021 - 10:45:13 AM
Last modification on : Tuesday, June 22, 2021 - 3:52:57 AM

No more hypoglycaemia on days with physical activity and unrestricted diet when using a closed‐loop system for 12 weeks: A post‐hoc secondary analysis of the multicentre randomized controlled Diabeloop WP7 trial

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No more hypoglycaemia on days with physical activity and unrestricted diet when using a closed‐loop system for 12 weeks: A post‐hoc secondary analysis of the multicentre randomized controlled Diabeloop WP7 trial

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