Panniculitis in a Woman With Opportunistic Pulmonary Coinfection by Pneumocystis jirovecii and Cryptococcus neoformans

Billal Tedbirt , Anne-Benedicte Duval-Modeste , Philippe Courville , Stéphane Dominique , Pierre Vera (1) , Hamza Regaieg

1 QuantIF-LITIS - Equipe Quantification en Imagerie Fonctionnelle

A 56-year-old woman, with history of psoriasis well controlled on ustekinumab, underwent 18F-FDG PET/CT to explore first onset of histologically proven skin panniculitis of unknown origin. PET/CT showed high uptake in panniculitis lesions in limbs and in a lung opacity suggestive of pneumonia. Based on PET/CT findings, a bronchoalveolar lavage revealed pulmonary coinfection by Pneumocystis jirovecii and Cryptococcus neoformans. Thus, hematogenous dissemination of infection was suspected as etiology of panniculitis. She was treated with fluconazole and trimethoprim-sulfamethoxazole, leading to total resolution of skin lesions. Posttherapeutic PET/CT showed complete metabolic response of skin and pulmonary lesions.

Domaines: Sciences du Vivant [q-bio]

Billal Tedbirt, Anne-Benedicte Duval-Modeste, Philippe Courville, Stéphane Dominique, Pierre Vera, et al.. Panniculitis in a Woman With Opportunistic Pulmonary Coinfection by Pneumocystis jirovecii and Cryptococcus neoformans. Clinical Nuclear Medicine, 2021, 46 (4), pp.e210-e211. ⟨10.1097/RLU.0000000000003420⟩. ⟨hal-03226501⟩