Skip to Main content Skip to Navigation
Journal articles

Immunosenescence patterns differ between populations but not between sexes in a long-lived mammal

Abstract : In animals, physiological mechanisms underlying reproductive and actuarial senescence remain poorly understood. Immunosenescence, the decline in the ability to display an efficient immune response with increasing age, is likely to influence both reproductive and actuarial senescence through increased risk of disease. Evidence for such a link has been reported from laboratory animal models but has been poorly investigated in the wild, where variation in resource acquisitions usually drives life-history tradeoffs. We investigated immunosenescence patterns over 7 years in both sexes of two contrasting roe deer populations (Capreolus capreolus). We first measured twelve immune markers to obtain a thorough identification of innate and adaptive components of immunity and assessed, from the same individuals, the age-dependent variation observed in parasitic infections. Although the level of innate traits was maintained at old age, the functional innate immune traits declined with increasing age in one of two populations. In both populations, the production of inflammatory markers increased with advancing age. Finally, the adaptive response declined in late adulthood. The increasing parasite burden with age we reported suggests the effective existence of immunosenescence. Age-specific patterns differed between populations but not between sexes, which indicate that habitat quality could shape agedependent immune phenotype in the wild.
Complete list of metadata
Contributor : Emmanuelle Gilot Connect in order to contact the contributor
Submitted on : Thursday, May 13, 2021 - 9:01:34 AM
Last modification on : Wednesday, August 3, 2022 - 3:41:20 AM


Publisher files allowed on an open archive



Louise Cheynel, Jean-François Lemaître, Jean-Michel Gaillard, Benjamin Rey, Gilles Bourgoin, et al.. Immunosenescence patterns differ between populations but not between sexes in a long-lived mammal. Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-13686-5⟩. ⟨hal-03225790⟩



Record views


Files downloads