Limits of a Glucose-Insulin Model to Investigate Intestinal Absorption in Type 2 Diabetes

Danilo Dursoniah (1) , Maxime Folschette (1) , Cédric Lhoussaine (1) , Rebecca Goutchtat (2) , François Pattou (2) , Violeta Raverdy (2)

1 BioComputing
2 RTD - Recherche translationnelle sur le diabète - U 1190

Abnormal regulation of glucose absorption in the small intestine is an important cause of Type 2 Diabetes (T2D). Even if this hypothesis is clinically well-known, it has not been fundamentally validated yet, mainly due to a lack of reliable metabolic knowledge on the glucose regulation. The main objective of this paper is to test this hypothesis on a highly referenced model composed of ordinary differential equations. This model is tested on an original dataset featuring the observations of obese diabetic patients. It shows its limits to predict our post-prandial glycemia and insulinemia time series especially with regard to the crucial complexity of gastro-intestinal regulation.

Mots clés: Ordinary Differential Equation; Systems Biology; Type 2 Diabetes; Intestinal Glucose Absorption

Domaines: Bio-Informatique, Biologie Systémique [q-bio.QM]

Danilo Dursoniah, Maxime Folschette, Cédric Lhoussaine, Rebecca Goutchtat, François Pattou, et al.. Limits of a Glucose-Insulin Model to Investigate Intestinal Absorption in Type 2 Diabetes. BIOTECHNO 2021 : The Thirteenth International Conference on Bioinformatics, Biocomputational Systems and Biotechnologies, Birgit Gersbeck-Schierholz; Hesham H. Ali, May 2021, Valencia, Spain. pp.4-7. ⟨hal-03216583⟩