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Phenolic composition and prospective anti-infectious properties of Atriplex lindleyi

Abstract : Objective: To investigate the antiplasmodial, antimicrobial, radical scavenging effects and to identifiy the phenolic constituents of Atriplex lindleyi (A. lindleyi). Methods: A. lindleyi extracts and some isolated compounds were tested in vitro against the chloroquine-resistant strains of lasmodium falciparum. The radical scavenging activity was quantified by using 2,2-diphenyl-2-picrylhydrazyl nitrogen-centered free radical. The IC50 of each extract was compared with references. The in vitro anti-infectious activity of extracts was evaluated against representative Gram-positive and Gram-negative bacterial strains [Staphylococcus aureus CIP 4.83, Enterococcus hirae CIP 5855, Pseudomonas aeruginosa (P. aeruginosa) CIP 82118, Escherichia coli CIP 53126], and fungal species [(Candida albicans (C. albicans) IP 48.72, Aspergillus niger IP 1431.83]. Ethanol extract was investigated for chemical composition through column and high performance liquid chromatography. The isolated compounds were identified by mass spectrometry and nuclear magnetic resonance. Results: Quercetin-7-O-arabinopyranoside-3-O-neohesperidosides (1), quercetin-3-O-arabinopyranosyl(1→6) glucopyranoside (2), quercetin-3-O-glucopyranoside-7-O-rhamnopyranoside (3), quercetin-3-O-glucopyranoside-7-O-arabinoside (4), schaftoside (5), quercetin-7-O-glucopyranoside (6) were isolated for the first time from the ethanol extract of A. lindleyi aerial parts in addition to isorhamnetin-3-O-β-glucopyranoside (7) and quercetin (8). The extracts exhibited moderate antiplasmodial activity with IC50≈ranging from 10–50 µg/mL. Quercetin was the most potent compound with IC50 of 9 µg/mL. P. aeruginosa and C. albicans were the most susceptible organisms. Conclusions: The study implies that A. lindelyi can contribute to the fight against malaria, and be useful as prophylactic against C. albicans and P. aeruginosa.
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Submitted on : Wednesday, January 19, 2022 - 2:30:50 PM
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Sahar Salah El Din El Souda, Azza Abdelmageed Matloub, Françoise Nepveu, Alexis Valentin, Christine Roques. Phenolic composition and prospective anti-infectious properties of Atriplex lindleyi. Asian Pacific Journal of Tropical Disease, Editorial office of Hainan Medical University, 2015, 5 (10), pp.786-791. ⟨10.1016/S2222-1808(15)60931-8⟩. ⟨hal-03215684⟩



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