Determination of the glass transition temperature of difficult samples by Flash DSC

Yohann Corvis (1) , Philippe Espeau (1) , Andreas Wurm (2) , Christoph Schick (2)

1 UPD5 Pharmacie - Faculté de Pharmacie de Paris - Université Paris Descartes
2 Université Rostock

Crystalline pharmaceutical substances often decompose immediately before or during melting. To determine the glass transition temperature, the substance must be melted and then cooled as rapidly as possible so that decomposition and crystallization do not occur. In many cases, the heating and cooling rates of conventional DSCs are not high enough for this purpose. The METTLER TOLEDO Flash DSC however offers new possibilities. This is illustrated in this article using prednisolone as an example.

Domaines: Chimie; Sciences de l'ingénieur [physics]; Sciences du Vivant [q-bio]; Médecine humaine et pathologie

Yohann Corvis, Philippe Espeau, Andreas Wurm, Christoph Schick. Determination of the glass transition temperature of difficult samples by Flash DSC. 2017. ⟨hal-03207018⟩