Engineered non-invasive functionalized dendrimer/dendron-entrapped/complexed gold nanoparticles as a novel class of theranostic (radio)pharmaceuticals in cancer therapy

Serge Mignani (1, 2) , Xiangyang Shi (3) , Valentin Ceña (4) , João Rodrigues (2) , Helena Tomas (2) , Jean Pierre Majoral (5)

1 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
2 Centro de Química da Madeira
3 CCEB - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University
4 UCLM - Universidad de Castilla-La Mancha = University of Castilla-La Mancha
5 LCC - Laboratoire de chimie de coordination

Nanomedicine represents a very significant contribution in current cancer treatment; in addition to surgical intervention, radiation and chemotherapeutic agents that unfortunately also kill healthy cells, inducing highly deleterious and often life-threatening side effects in the patient. Of the numerous nanoparticles used against cancer, gold nanoparticles had been developed for therapeutic applications. Inter alia, a large variety of dendrimers, i.e. soft artificial macromolecules, have turned up as non-viral functional nanocarriers for entrapping drugs, imaging agents, and targeting molecules. This review will provide insights into the design, synthesis, functionalization, and development in biomedicine of engineered functionalized hybrid dendrimer-tangled gold nanoparticles in the domain of cancer theranostic. Several aspects are highlighted and discussed such as 1) dendrimer-entrapped gold(0) hybrid nanoparticles for the targeted imaging and treatment of cancer cells, 2) dendrimer encapsulating gold(0) nanoparticles (Au DENPs) for the delivery of genes, 3) Au DENPs for drug delivery applications, 4) dendrimer encapsulating gold radioactive nanoparticles for radiotherapy, and 5) dendrimer/dendron-complexed gold(III) nanoparticles as technologies to take down cancer cells.

Mots clés: Dendrimers; Dendrons; Gold(0)/(III) nanoparticles; Gene and drug delivery; Cancer therapy; Theranostic strategy

Domaines: Chimie de coordination

Serge Mignani, Xiangyang Shi, Valentin Ceña, João Rodrigues, Helena Tomas, et al.. Engineered non-invasive functionalized dendrimer/dendron-entrapped/complexed gold nanoparticles as a novel class of theranostic (radio)pharmaceuticals in cancer therapy. Journal of Controlled Release, 2021, 332, pp.346-366. ⟨10.1016/j.jconrel.2021.03.003⟩. ⟨hal-03203301⟩