Lung cancer risk in painters: results from the SYNERGY pooled case-control study consortium

Neela Guha (1) , Liacine Bouaoun (1) , Hans Kromhout (2) , Roel Vermeulen (2) , Thomas Bruening (3) , Thomas Behrens (3) , Susan Peters (2) , Veronique Luzon (1) , Jack Siemiatycki (4) , Mengting Xu (4) , Benjamin Kendzia (3) , Pascal Guenel (5) , Danièle Luce (6) , Stefan Karrasch (7) , Heinz-Erich Wichmann (7) , Dario Consonni (8) , Maria Teresa Landi (9) , Neil E. Caporaso (9) , Per Gustavsson (10) , Nils Plato (10) , Franco Merletti (11) , Dario Mirabelli (11) , Lorenzo Richiardi (11) , Karl-Heinz Jockel (12) , Wolfgang Ahrens (13) , Hermann Pohlabeln (13) , Lap Ah Tse (14) , Ignatius Tak-Sun Yu (14) , Adonina Tardon (15) , Paolo Boffetta (16) , David Zaridze (17) , Andrea'T Mannetje (18) , Neil Pearce (19) , Michael P. A. Davies (20) , Jolanta Lissowska (21) , Beata Swiatkowska (22) , John Mclaughlin (23) , Paul A. Demers (24) , Vladimir Bencko (25) , Lenka Foretova (26) , Vladimir Janout (27) , Tamas Pandics (28) , Eleonora Fabianova (29) , Dana Mates (30) , Francesco Forastiere (31) , Bas Bueno-De-Mesquita (32) , Joachim Schuz (1) , Kurt Straif (1) , Ann Olsson (1)

1 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
2 IRAS - Institute for Risk Assessment Sciences [Utrecht]
3 IPA - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
4 ESPUM - Département de médecine sociale et préventive [ESPUM-Montréal]
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 Irset - Institut de recherche en santé, environnement et travail
7 German Research Center for Environmental Health - Helmholtz Center München (GmbH)
8 Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
9 NCI-NIH - National Cancer Institute [Bethesda]
10 Karolinska Institute
11 UNITO - Università degli studi di Torino = University of Turin
12 Ruhrlandklinik University Hospital
13 Leibniz Institute for Prevention Research and Epidemiology - BIPS
14 CUHK - The Chinese University of Hong Kong [Hong Kong]
15 University of Oviedo
16 SBU - Stony Brook University [SUNY]
17 N.N. Blokhin National Medical Research Center of Oncology
18 Massey University
19 LSHTM - London School of Hygiene and Tropical Medicine
20 University of Liverpool
21 MCMCC - Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
22 NIOM - Nofer Institute of Occupational Medicine
23 University of Toronto
24 Occupational Cancer Research Centre
25 1. LF UK / 1st Faculty of Medicine - 1. lékařská fakulta, Univerzita Karlova [Praha, Česká republika] = First Faculty of Medicine, Charles University [Prague, Czech Republic]
26 MMCI - Masaryk Memorial Cancer Institute
27 Palacky University Olomouc
28 National Public Health Centre,
29 RAPH - Regional Authority of Public Health [Slovaquia]
30 INSP - National Institute of Public Health [Romania]
31 ASL - Azienda Sanitaria Locale [ROMA]
32 RIVM - National Institute for Public Health and the Environment [Bilthoven]

Objectives We evaluated the risk of lung cancer associated with ever working as a painter, duration of employment and type of painter by histological subtype as well as joint effects with smoking, within the SYNERGY project. Methods Data were pooled from 16 participating case-control studies conducted internationally. Detailed individual occupational and smoking histories were available for 19 369 lung cancer cases (684 ever employed as painters) and 23 674 age-matched and sex-matched controls (532 painters). Multivariable unconditional logistic regression models were adjusted for age, sex, centre, cigarette pack-years, time-since-smoking cessation and lifetime work in other jobs that entailed exposure to lung carcinogens. Results Ever having worked as a painter was associated with an increased risk of lung cancer in men (OR 1.30; 95% CI 1.13 to 1.50). The association was strongest for construction and repair painters and the risk was elevated for all histological subtypes, although more evident for small cell and squamous cell lung cancer than for adenocarcinoma and large cell carcinoma. There was evidence of interaction on the additive scale between smoking and employment as a painter (relative excess risk due to interaction >0). Conclusions Our results by type/industry of painter may aid future identification of causative agents or exposure scenarios to develop evidence-based practices for reducing harmful exposures in painters.

Mots clés: cancer; epidemiology; painters; smoking

Domaines: Sciences du Vivant [q-bio]

Neela Guha, Liacine Bouaoun, Hans Kromhout, Roel Vermeulen, Thomas Bruening, et al.. Lung cancer risk in painters: results from the SYNERGY pooled case-control study consortium. Occupational and Environmental Medicine, 2021, 78 (4), pp.269-278. ⟨10.1136/oemed-2020-106770⟩. ⟨hal-03203232⟩