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Thermosensitive vesicles from chemically encoded lipid-grafted elastin-like polypeptides.

Vusala Ibrahimova 1 Hang Zhao 1 Emmanuel Ibarboure 1 Elisabeth Garanger 1, * Sébastien Lecommandoux 1, *
* Corresponding author
1 Team 3 LCPO : Polymer Self-Assembly & Life Sciences
LCPO - Laboratoire de Chimie des Polymères Organiques
Abstract : Biomimetic design to afford smart functional biomaterials with exquisite properties represents synthetic challenges and provides unique perspectives. In this context, elastin-like polypeptides (ELPs) recently became highly attractive building blocks in the development of lipoprotein-based membranes. In addition to the bioengineered post-translational modifications of genetically encoded recombinant ELPs developed so far, we report here a simple and versatile method to design biohybrid brush-like lipid-grafted-ELPs using chemical post-modification reactions. We have explored a combination of methionine alkylation and click chemistry to create a new class of hybrid lipoprotein mimics. Our design allowed the formation of biomimetic vesicles with controlled permeability, correlated to the temperature-responsiveness of ELPs.
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https://hal.archives-ouvertes.fr/hal-03200716
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Submitted on : Friday, April 16, 2021 - 5:17:39 PM
Last modification on : Sunday, June 27, 2021 - 5:04:38 PM
Long-term archiving on: : Saturday, July 17, 2021 - 7:16:49 PM

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Vusala Ibrahimova, Hang Zhao, Emmanuel Ibarboure, Elisabeth Garanger, Sébastien Lecommandoux. Thermosensitive vesicles from chemically encoded lipid-grafted elastin-like polypeptides.. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, 60 (27), pp.15036-15040. ⟨10.1002/anie.202102807⟩. ⟨hal-03200716⟩

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