Thermosensitive vesicles from chemically encoded lipid-grafted elastin-like polypeptides.
Résumé
Biomimetic design to afford smart functional biomaterials with exquisite properties represents synthetic challenges and provides unique perspectives. In this context, elastin-like polypeptides (ELPs) recently became highly attractive building blocks in the development of lipoprotein-based membranes. In addition to the bioengineered post-translational modifications of genetically encoded recombinant ELPs developed so far, we report here a simple and versatile method to design biohybrid brush-like lipid-grafted-ELPs using chemical post-modification reactions. We have explored a combination of methionine alkylation and click chemistry to create a new class of hybrid lipoprotein mimics. Our design allowed the formation of biomimetic vesicles with controlled permeability, correlated to the temperature-responsiveness of ELPs.
Fichier principal
Ibrahimova et al AngewChem2021 author ms with ESI.pdf (3.5 Mo)
Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
