Death sentence: The tale of a fallen endoplasmic reticulum

Eoghan P Mcgrath (1) , Federica G Centonze (1) , Eric Chevet (1, 2) , Tony Avril (1, 2) , Elodie Lafont (1)

1 COSS - Chemistry, Oncogenesis, Stress and Signaling
2 CRLCC - CRLCC Eugène Marquis

Endoplasmic Reticulum (ER) stress signaling is an adaptive mechanism triggered when protein folding demand overcomes the folding capacity of this compartment, thereby leading to the accumulation of improperly folded proteins. This stress signaling pathway is named the Unfolded Protein Response (UPR) and aims at restoring ER homeostasis. However, if this fails, mechanisms orienting cells towards death processes are initiated. Herein, we summarize the most recent findings connecting ER stress and the UPR with identified death mechanisms including apoptosis, necrosis, pyroptosis, ferroptosis, and autophagy. We highlight new avenues that could be investigated and controlled through actionable mechanisms in physiology and pathology.

Mots clés: Apoptosis; Autophagy; Cell death; Endoplasmic reticulum; Ferroptosis; Pyroptosis; Unfolded protein response

Domaines: Cancer

Eoghan P Mcgrath, Federica G Centonze, Eric Chevet, Tony Avril, Elodie Lafont. Death sentence: The tale of a fallen endoplasmic reticulum. Biochimica et Biophysica Acta - Molecular Cell Research, 2021, 1868 (6), pp.119001. ⟨10.1016/j.bbamcr.2021.119001⟩. ⟨hal-03194479⟩