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Comparative Methods for Reconstructing Ancient Genome Organization

Yoann Anselmetti Nina Luhmann Sèverine Bérard Eric Tannier 1, 2 Cedric Chauve
2 BEAGLE - Artificial Evolution and Computational Biology
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Comparative genomics considers the detection of similarities and differences between extant genomes, and, based on more or less formalized hypotheses regarding the involved evolutionary processes, inferring ancestral states explaining the similarities and an evolutionary history explaining the differences. In this chapter, we focus on the reconstruction of the organization of ancient genomes into chromosomes. We review different methodological approaches and software, applied to a wide range of datasets from different kingdoms of life and at different evolutionary depths. We discuss relations with genome assembly, and potential approaches to validate computational predictions on ancient genomes that are almost always only accessible through these predictions.
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Submitted on : Thursday, April 8, 2021 - 8:24:32 AM
Last modification on : Tuesday, July 20, 2021 - 5:20:04 PM


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Yoann Anselmetti, Nina Luhmann, Sèverine Bérard, Eric Tannier, Cedric Chauve. Comparative Methods for Reconstructing Ancient Genome Organization. Comparative Genomics: Methods and Protocols, pp.343 - 362, 2017, ⟨10.1007/978-1-4939-7463-4_13⟩. ⟨hal-03192460⟩



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