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Article Dans Une Revue Molecules Année : 2021

Marine Exopolysaccharide Complexed With Scandium Aimed as Theranostic Agents

Résumé

Background: Exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium, showed anti-metastatic properties. They may represent a new class of ligands to be combined with theranostic radionuclides, such as 47Sc/44Sc. The goal of this work was to investigate the feasibility of such coupling. Methods: EPSs, as well as heparin used as a drug reference, were characterized in terms of molar mass and dispersity using Asymmetrical Flow Field-Flow Fractionation coupled to Multi-Angle Light Scattering (AF4-MALS). The intrinsic viscosity of EPSs at different ionic strengths were measured in order to establish the conformation. To determine the stability constants of Sc with EPS and heparin, a Free-ion selective radiotracer extraction (FISRE) method has been used. Results: AF4-MALS showed that radical depolymerization produces monodisperse EPSs, suitable for therapeutic use. EPS conformation exhibited a lower hydrodynamic volume for the highest ionic strengths. The resulting random-coiled conformation could affect the complexation with metal for high concentration. The LogK of Sc-EPS complexes have been determined and showing that they are comparable to the Sc-Hep. Conclusions: EPSs are very promising to be coupled with the theranostic pair of scandium for Nuclear Medicine
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hal-03187695 , version 1 (25-05-2021)

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Mattia Mazza, Cyrille Alliot, Corinne Sinquin, Sylvia Colliec-Jouault, Pascal E Reiller, et al.. Marine Exopolysaccharide Complexed With Scandium Aimed as Theranostic Agents. Molecules, 2021, 2021-02-20, 26 (4), pp.1143. ⟨10.3390/molecules26041143⟩. ⟨hal-03187695⟩
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