Long-term outcome in patients with aneurysmal subarachnoid hemorrhage requiring mechanical ventilation

Kevin Chalard (1, 2) , Vivien Szabo (1, 2) , Frederique Pavillard (1) , Flora Djanikian (1) , Cyril Dargazanli (1) , Nicolas Molinari (3) , Federico Manna (4) , Vincent Costalat (1) , Gerald Chanques (5) , Pierre-Francois Perrigault (1)

1 Hôpital Gui de Chauliac [CHU Montpellier]
2 IGF - Institut de Génomique Fonctionnelle
3 IMAG - Institut Montpelliérain Alexander Grothendieck
4 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
5 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]

Background: Patients affected with aneurysmal subarachnoid hemorrhage (aSAH) often require intensive care, and then present distinctive outcome from less severe patients. We aimed to specify their long-term outcome and to identify factors associated with poor outcome. Methods: We conducted a retrospective study in a French university hospital intensive care unit. Patients with aSAH requiring mechanical ventilation hospitalized between 2010 and 2015 were included. At least one year after initial bleeding, survival and degree of disability were assessed using the modified Rankin Scale (mRS) via telephone interviews. A multivariable logistic regression analysis was performed to determine independent factors associated with poor outcome defined as mRS≥3. Results: Two-hundred thirty-six patients were included. Among them, 7 were lost to follow-up, and 229 were analyzed: 73 patients (32%) had a good outcome (mRS<3), and 156 (68%) had a poor outcome (mRS≥3). The estimated 1-year survival rate was 63%. One-hundred sixty-three patients patients (71%) suffered from early brain injuries (EBI), 33 (14%) from rebleeding, 80 (35%) from vasospasm and 63 (27%) from delayed cerebral ischemia (DCI). Multivariable logistic regression identified independent factors associated with poor outcome including delay between aSAH diagnosis and mRS assessment (OR, 0.96; 95% CI, 0.95-0.98; p<.0001), age (OR per 10 points, 1.57; 95% CI, 1.12-2.19; p = 0.008), WFNS V versus WFNS III (OR, 5.71; 95% CI 1.51-21.61; p = 0.004), subarachnoid rebleeding (OR, 6.47; 95% CI 1.16-36.06; p = 0.033), EBI (OR, 4.52; 95% CI 1.81-11.29; p = 0.001) and DCI (OR, 4.73; 95% CI, 1.66-13.49; p = 0.004). Conclusion: Among aSAH patients requiring assisted ventilation, two-third of them survived at one year, and one-third showed good long-term outcome. As it appears as an independant factor associated with poor outcome, DCI shoud retain particular attention in future studies beyond angiographic vasospasm.

Domaines: Cardiologie et système cardiovasculaire; Neurosciences [q-bio.NC]; Santé publique et épidémiologie

Kevin Chalard, Vivien Szabo, Frederique Pavillard, Flora Djanikian, Cyril Dargazanli, et al.. Long-term outcome in patients with aneurysmal subarachnoid hemorrhage requiring mechanical ventilation. PLoS ONE, 2021, 16 (3), pp.e0247942. ⟨10.1371/journal.pone.0247942⟩. ⟨hal-03170582v2⟩