The winding road towards an atropo-enantioselective 'ARYNE coupling'

David Augros (1) , Corinne Comoy (2) , Yves Fort (2) , Frédéric Leroux (1) , Armen Panossian (1)

1 LIMA - Laboratoire d'innovation moléculaire et applications
2 L2CM - Laboratoire Lorrain de Chimie Moléculaire

For the first time, the challenging atropo-enantioselective coupling of in-situ generated arynes and aryllithiums in the presence of a chiral ligand of lithium was investigated. This preliminary study demonstrates the feasibility of this concept, by affording enantioenriched axially chiral biaryls even in the case of products showing a high degree of steric congestion around the newly created aryl–aryl bond.

Domaines: Chimie organique; Chimie

David Augros, Corinne Comoy, Yves Fort, Frédéric Leroux, Armen Panossian. The winding road towards an atropo-enantioselective 'ARYNE coupling'. European Journal of Organic Chemistry, 2021, ⟨10.1002/ejoc.202100087⟩. ⟨hal-03170152⟩