PREPARATION DE L'ACIDE AMINOMETHYLPHOSPHONIQUE α-DIDEUTERIE

Sylvie Berté-Verrando (1) , François Nief (1) , Carl Patois (1) , Philippe Savignac (1)

1 DCPH - Laboratoire Hétéroéléments et Coordination

Nucleophilic amination of chloromethylphosphonic esters was studied. α-Dideuteriared aminomethyl-phosphonic acid was obtained from bis(trifluoroethyl) chloromehylphosphonic ester and sodium azide through substitution of the chlorine, reduction of the azide and acidic hydrolysis. Incorporation of the deuterium was greater than 95% and overall yields were in the range 55-65%.

Mots clés: nucleophilic amination; chloromethylphosphonic esters; α-dideuteriated chloromethyl-phosphonic esters; sodium azide; aminomethylphosphonic acid; deuterium oxide; trifluoroethanol; α-dideuteriated aminomethylphosphonic acid

Domaines: Chimie organique

Sylvie Berté-Verrando, François Nief, Carl Patois, Philippe Savignac. PREPARATION DE L'ACIDE AMINOMETHYLPHOSPHONIQUE α-DIDEUTERIE. Phosphorus, Sulfur, and Silicon and the Related Elements, 1995, 103 (1-4), pp.91-100. ⟨10.1080/10426509508027368⟩. ⟨hal-03166580⟩