Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies

Anatoly Skalny (1) , Michael Aschner (2) , Yueming Jiang (3) , Yordanka Gluhcheva (4) , Yousef Tizabi (5) , Ryszard Lobinski (6) , Alexey Tinkov (1)

1 YSPU - Yaroslavl State Pedagogical University
2 Albert Einstein College of Medicine [New York]
3 Guangxi Medical University [Nanning, China]
4 BAS - Bulgarian Academy of Sciences
5 Howard University College of Medicine [Washington, DC, USA]
6 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux

Aluminum (Al) is considered as the most abundant metal in the Earth's crust, being the third most abundant chemical element after oxygen and silicon. Intensive development of the Al industry (Brough and Jouhara, 2020) due to a wide use of the metal has resulted in a significant increase in environmental Al levels (Crisponi et al., 2012). The sources of human Al exposure may include diet (Tietz et al., 2019), being responsible for 95% of total body Al (Goullé and Grangeot-Keros, 2020), drinking water (Krupińska, 2020), air (Exley, 2013), as well as cosmetics (Crisponi et al., 2012) and medicinal drugs, namely antacids (Klotz et al., 2017). Involvement in Al processing industry may also result in occupational Al exposure (Skalny et al., 2018). Earlier studies demonstrated that vaccination could be considered as a source of Al exposure due to the presence of aluminium adjuvants † Authors contributed equally to the research.

Domaines: Sciences du Vivant [q-bio]

Anatoly Skalny, Michael Aschner, Yueming Jiang, Yordanka Gluhcheva, Yousef Tizabi, et al.. Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies. Michael Aschner; Lucio G. Costa. Neurotoxicity of Metals: Old Issues and New Developments, 5, Elsevier, pp.1-34, 2021, Advances in Neurotoxicology, 978-0-12-823775-5. ⟨10.1016/bs.ant.2020.12.001⟩. ⟨hal-03147595⟩