Antimalarial activity of compounds comprising a primary benzene sulfonamide fragment

Katherine Andrews (1, 2) , Gillian Fisher (1, 2) , Subathdrage D.M. Sumanadasa (1, 2) , Tina Skinner-Adams (1, 2) , Janina Moeker (1) , Marie Lopez (1) , Sally-Ann Poulsen (1)

1 Eskitis Institute for Drug Discovery
2 Queensland Institute of Medical Research, Herston, Queensland 4029, Australia

Mots clés: Antimalarial; Carbonic anhydrase; NFF; Plasmodium falciparum; Primary sulfonamide; Ro5; SAR; SPR; Structure–activity relationships; Structure–property relationships; Sulfonamide; neonatal foreskin fibroblast; rule of 5 violations

Domaines: Chimie thérapeutique; Maladies infectieuses

Katherine Andrews, Gillian Fisher, Subathdrage D.M. Sumanadasa, Tina Skinner-Adams, Janina Moeker, et al.. Antimalarial activity of compounds comprising a primary benzene sulfonamide fragment. Bioorganic and Medicinal Chemistry Letters, 2013, 23 (22), pp.6114-6117. ⟨10.1016/j.bmcl.2013.09.015⟩. ⟨hal-03130480⟩