Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties

Cindy Carroux (1) , Janina Moeker (1) , Josephine Motte (1) , Marie Lopez (1) , Laurent Bornaghi (2) , Kasiram Katneni (3) , Eileen Ryan (3) , Julia Morizzi (3) , David Shackleford (3) , Susan Charman (3) , Sally-Ann Poulsen (1)

1 Eskitis Institute for Drug Discovery
2 Griffith University [Brisbane]
3 Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences

Mots clés: Carbohydrate; Prodrug; Esterase; Metabolic stability; Click chemistry; Azide

Domaines: Chimie thérapeutique; Chimie organique

Cindy Carroux, Janina Moeker, Josephine Motte, Marie Lopez, Laurent Bornaghi, et al.. Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties. Bioorganic and Medicinal Chemistry Letters, 2013, 23 (2), pp.455-459. ⟨10.1016/j.bmcl.2012.11.056⟩. ⟨hal-03130067⟩