Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases

Janina Moeker (1) , Kanae Teruya (1) , Sabine Rossit (1) , Brendan Wilkinson (1) , Marie Lopez (1) , Laurent Bornaghi (2) , Alessio Innocenti (3) , Claudiu Supuran (3) , Sally-Ann Poulsen (1)

1 Eskitis Institute for Drug Discovery
2 Griffith University [Brisbane]
3 LCBI-UniFI - Laboratorio di Chimica Bioinorganica [UniFI, Firenze] = Laboratory of Bioinorganic Chemistry [UniFI Florence]

Mots clés: Carbonic anhydrase; Thiourea; Carbohydrate; Inhibitor; Hypoxia

Domaines: Chimie organique; Chimie thérapeutique; Cancer

Janina Moeker, Kanae Teruya, Sabine Rossit, Brendan Wilkinson, Marie Lopez, et al.. Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases. Bioorganic and Medicinal Chemistry Letters, 2012, 20 (7), pp.2392-2404. ⟨10.1016/j.bmc.2012.01.052⟩. ⟨hal-03130049⟩