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Chromosomal scale assembly of parasitic wasp genome reveals symbiotic virus colonization

Jérémy Gauthier 1, 2 Hélène Boulain 3 Joke van Vugt 4 Lyam Baudry 5, 6 Emma Persyn 7 Jean-Marc Aury 8 Benjamin Noel 8 Anthony Bretaudeau 9, 10 Fabrice Legeai 9, 10 Sven Warris 11 Mohamed Chebbi 1 Géraldine Dubreuil 1 Bernard Duvic 12 Natacha Kremer 13 Philippe Gayral 1 Karine Musset 1 Thibaut Josse 1 Diane Bigot 1 Christophe Bressac 1 Sébastien Moreau 1 Georges Périquet 1 Myriam Harry 14 Nicolas Montagne 7 Isabelle Boulogne 7 Mahnaz Sabeti-Azad 7 Martine Maïbèche 7 Thomas Chertemps 7 Frédérique Hilliou 15 David Siaussat 7 Joëlle Amselem 16 Isabelle Luyten 16 Claire Capdevielle-Dulac 14 Karine Labadie 17 Bruna Laís Merlin 18 Valérie Barbe 17 Jetske de Boer 10 Martial Marbouty 5 Fernando Luis Cônsoli 18 Stéphane Dupas 14 Aurélie Hua-Van 14 Gaelle Le Goff 15 Annie Bézier 1 Emmanuelle Jacquin-Joly 7 James Whitfield 19 Louise Vet 20, 21 Hans Smid 20 Laure Kaiser 14 Romain Koszul 5 Elisabeth Huguet 1 Elisabeth Herniou 1 Jean-Michel Drezen 1, *
Abstract : Endogenous viruses form an important proportion of eukaryote genomes and a source of novel functions. How large DNA viruses integrated into a genome evolve when they confer a benefit to their host, however, remains unknown. Bracoviruses are essential for the parasitism success of parasitoid wasps, into whose genomes they integrated similar to 103 million years ago. Here we show, from the assembly of a parasitoid wasp genome at a chromosomal scale, that bracovirus genes colonized all ten chromosomes of Cotesia congregata. Most form clusters of genes involved in particle production or parasitism success. Genomic comparison with another wasp, Microplitis demolitor, revealed that these clusters were already established similar to 53mya and thus belong to remarkably stable genomic structures, the architectures of which are evolutionary constrained. Transcriptomic analyses highlight temporal synchronization of viral gene expression without resulting in immune gene induction, suggesting that no conflicts remain between ancient symbiotic partners when benefits to them converge. Jeremy Gauthier et al. present the chromosome scale assembly of the genome of the parasitic wasp C. congregata and show that bracovirus genes have colonized all ten chromosomes. Comparison with genome scaffolds of another wasp reveals a striking stability of these regions over similar to 53 million years, suggesting strong evolutionary constraints.
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Submitted on : Monday, February 1, 2021 - 4:24:03 PM
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Jérémy Gauthier, Hélène Boulain, Joke van Vugt, Lyam Baudry, Emma Persyn, et al.. Chromosomal scale assembly of parasitic wasp genome reveals symbiotic virus colonization. Communications Biology, Nature Publishing Group, 2021, 4 (1), ⟨10.1038/s42003-020-01623-8⟩. ⟨hal-03127732⟩



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