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Taking advantage of pathogen diversity and immune priming to minimize disease prevalence in host mixtures: a model

Pauline Clin 1 Frédéric Grognard 2, 3 Ludovic Mailleret 4 Florence Val 1 Didier Andrivon 1 Frédéric Hamelin 1, *
* Corresponding author
2 BIOCORE - Biological control of artificial ecosystems
CRISAM - Inria Sophia Antipolis - Méditerranée , LOV - Laboratoire d'océanographie de Villefranche, INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement
Abstract : Host mixtures are a promising method for agroecological plant disease control. Plant immunity is key to the success of host mixtures against polymorphic pathogen populations. This results from priming-induced cross-protection, whereby plants able to resist infection by specific pathogen genotypes become more resistant to other pathogen genotypes. Strikingly, this phenomenon was thus far absent from mathematical models aiming at designing host mixtures. We developed a model to specifically explore how priming affects the coexistence of two pathogen genotypes in host mixtures composed of two host genotypes, and how it impacts disease prevalence. The main effect of priming is to reduce the coexistence region in the parameter space (due to cross protection), and to generate a singular mixture of resistant/susceptible hosts corresponding to the maximal reduction disease prevalence (in absence of priming, a resistant pure stand is optimal). The epidemiological advantage of host mixtures over a resistant pure stand thus appears as a direct consequence of immune priming. We also showed that there is indirect cross-protection between host genotypes in a mixture. Moreover, the optimal mix prevents the emergence of a resistance-breaking pathogen genotype. Our results highlight the importance of considering immune priming to design optimal and sustainable host mixtures.
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https://hal.archives-ouvertes.fr/hal-03124229
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Submitted on : Thursday, January 28, 2021 - 5:07:04 PM
Last modification on : Monday, May 31, 2021 - 9:02:06 AM
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Pauline Clin, Frédéric Grognard, Ludovic Mailleret, Florence Val, Didier Andrivon, et al.. Taking advantage of pathogen diversity and immune priming to minimize disease prevalence in host mixtures: a model. Phytopathology, American Phytopathological Society, 2020, ⟨10.1094/PHYTO-09-20-0429-R⟩. ⟨hal-03124229⟩

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