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Interpolation and averaging of diffusion MRI multi-compartment models

Renaud Hédouin 1 Christian Barillot 1 Olivier Commowick 1
1 Empenn
INSERM - Institut National de la Santé et de la Recherche Médicale, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : Multi-compartment models (MCM) are increasingly used to characterize the brain white matter microstructure from diffusion-weighted imaging (DWI). Their use in clinical studies is however limited by the inability to resample an MCM image towards a common reference frame, or to construct atlases from such brain microstructure models. We propose to solve this problem by first identifying that these two tasks amount to the same problem. We propose to tackle it by viewing it as a simplification problem, solved thanks to spectral clustering and the definition of semi-metrics between several usual compartments encountered in the MCM literature. This generic framework is evaluated for two models: the multi-tensor model where individual fibers are modeled as individual tensors and the diffusion direction imaging (DDI) model that differentiates intra-and extra-axonal components of each fiber. Results on simulated data, simulated transformations and real data show the ability of our method to well interpolate MCM images of these types. We finally present as an application an MCM template of normal controls constructed using our approach.
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https://hal.archives-ouvertes.fr/hal-03110559
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Submitted on : Thursday, January 14, 2021 - 4:37:28 PM
Last modification on : Thursday, January 20, 2022 - 5:28:54 PM
Long-term archiving on: : Thursday, April 15, 2021 - 7:16:49 PM

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Renaud Hédouin, Christian Barillot, Olivier Commowick. Interpolation and averaging of diffusion MRI multi-compartment models. IEEE Transactions on Medical Imaging, Institute of Electrical and Electronics Engineers, 2021, 40 (3), pp.916-927. ⟨10.1109/tmi.2020.3042765⟩. ⟨hal-03110559⟩

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