Current Applications of Artificial Metalloenzymes and Future Developments

Jean-Pierre Mahy (1) , Frédéric Avenier (1) , Wadih Ghattas (1) , Rémy Ricoux (1) , Michele Salmain (2)

1 ICMMO - Institut de Chimie Moléculaire et des Matériaux d'Orsay
2 IPCM - Institut Parisien de Chimie Moléculaire

In between traditional homogeneous metal catalysts and enzyme catalysts, a new class of hybrid catalysts named artificial metalloenzymes resulting from the controlled embedding of transition metal species (ions, synthetic inorganic or organometallic complexes) within natural, genetically-engineered or even de novo protein scaffolds currently undergoes a tremendous development at the academic level. This family of hybrid assemblies ideally combines the features of their individual components, allowing a wide range of chemical reactions, including new-to-nature reactions, to be catalyzed under mild, eco-compatible conditions with high chemo-and/or stereoselectivity. This chapter intends to summarize the most remarkable achievements in artificial metalloenzyme design and properties with emphasis put on industrially relevant chemical reactions, including oxidations, imine reductions, CC and C-N bonds formation. It also gives an up-to-date survey on the most advanced applications of artificial metalloenzymes in cascade reactions and in vivo catalysis.

Domaines: Catalyse; Chimie; Chimie de coordination; Chimie inorganique

Jean-Pierre Mahy, Frédéric Avenier, Wadih Ghattas, Rémy Ricoux, Michele Salmain. Current Applications of Artificial Metalloenzymes and Future Developments. Enzymes for Solving Humankind's Problems, pp.363 - 411, 2020, ⟨10.1007/978-3-030-58315-6_12⟩. ⟨hal-03100142⟩