Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory

Poonam Bheda , Diana Aguilar-Gómez , Nils Becker , Johannes Becker , Emmanouil Stavrou , Igor Kukhtevich , Thomas Höfer , Sebastian Maerkl , Gilles Charvin (1) , Carsten Marr , Antonis Kirmizis , Robert Schneider

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire

Highlights d Single yeast cells maintain memory of gene induction and transmit it to naive progeny d Pedigree analysis shows memory capacity is similar within lineages d Screens reveal chromatin factors involved in memory maintenance and/or inheritance d A memory mutant is identified with enhanced reinduction memory

Domaines: Génétique; Sciences du Vivant [q-bio]

Poonam Bheda, Diana Aguilar-Gómez, Nils Becker, Johannes Becker, Emmanouil Stavrou, et al.. Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory. Molecular Cell, 2020, 78 (5), pp.915-925.e7. ⟨10.1016/j.molcel.2020.04.016⟩. ⟨hal-03096857⟩