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Brushite (Ca,M)HPO4, 2H2O doping with bioactive ions (M = Mg2+, Sr2+, Zn2+, Cu2+, and Ag+): a new path to functional biomaterials?

Abstract : Dicalcium phosphate dihydrate, DCPD (CaHPO 4 .2H 2 O), brushite, is an important CaP compound encountered in mineralized tissues and used in medicine, especially in bone cement formulations. However, the use of DCPD as direct implantable biomaterial has not received dedicated attention. Also, the possibility to dope DCPD with biologically-active ions to modulate its performances was not systematically explored. We have investigated in depth the doping of DCPD with Mg 2+ , Sr 2+ , Zn 2+ , Cu 2+ and Ag + ions. Clear modifications in terms of chemical composition, particle size, pore distribution, crystal morphology and affinity for water were pointed out. Then, the samples were cultured with human adipose-derived stem cells (ADSCs) to explore cytotoxicity and proliferation. Various behaviors were noticed dependent on the incorporated metal ions. Such DCPD compounds associated with bioactive metal ions, and particularly Ag + and Zn 2+ , appear promising as a new family of reactive materials for use, as such or in combination, in bone-related applications.
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https://hal.archives-ouvertes.fr/hal-03095419
Contributor : Christophe Drouet <>
Submitted on : Monday, January 4, 2021 - 4:11:13 PM
Last modification on : Friday, January 8, 2021 - 3:27:34 AM

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Moufida Sayahi, Jerran Santos, Hafed El-Feki, Cédric Charvillat, Françoise Bosc, et al.. Brushite (Ca,M)HPO4, 2H2O doping with bioactive ions (M = Mg2+, Sr2+, Zn2+, Cu2+, and Ag+): a new path to functional biomaterials?. Materials Today Chemistry, Elsevier, 2020, 16, pp.100230. ⟨10.1016/j.mtchem.2019.100230⟩. ⟨hal-03095419⟩

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