Brushite (Ca,M)HPO4, 2H2O doping with bioactive ions (M = Mg2+, Sr2+, Zn2+, Cu2+, and Ag+): a new path to functional biomaterials?

Moufida Sayahi (1) , Jerran Santos , Hafed El-Feki (2) , Cédric Charvillat (1) , Françoise Bosc (1) , Ipek Karacan , Bruce Milthorpe , Christophe Drouet (1)

1 CIRIMAT - Centre interuniversitaire de recherche et d'ingenierie des matériaux
2 FSS - Faculté des Sciences de Sfax

Dicalcium phosphate dihydrate, DCPD (CaHPO 4 .2H 2 O), brushite, is an important CaP compound encountered in mineralized tissues and used in medicine, especially in bone cement formulations. However, the use of DCPD as direct implantable biomaterial has not received dedicated attention. Also, the possibility to dope DCPD with biologically-active ions to modulate its performances was not systematically explored. We have investigated in depth the doping of DCPD with Mg 2+ , Sr 2+ , Zn 2+ , Cu 2+ and Ag + ions. Clear modifications in terms of chemical composition, particle size, pore distribution, crystal morphology and affinity for water were pointed out. Then, the samples were cultured with human adipose-derived stem cells (ADSCs) to explore cytotoxicity and proliferation. Various behaviors were noticed dependent on the incorporated metal ions. Such DCPD compounds associated with bioactive metal ions, and particularly Ag + and Zn 2+ , appear promising as a new family of reactive materials for use, as such or in combination, in bone-related applications.

Mots clés: Brushite; DCPD; ion substitution; human stem cells; bone biomaterial; calcium phosphate

Domaines: Chimie

Moufida Sayahi, Jerran Santos, Hafed El-Feki, Cédric Charvillat, Françoise Bosc, et al.. Brushite (Ca,M)HPO4, 2H2O doping with bioactive ions (M = Mg2+, Sr2+, Zn2+, Cu2+, and Ag+): a new path to functional biomaterials?. Materials Today Chemistry, 2020, 16, pp.100230. ⟨10.1016/j.mtchem.2019.100230⟩. ⟨hal-03095419⟩