In vitro infection of primary human hepatocytes by HCV-positive sera: insights on a highly relevant model

Claire Gondeau (1) , Philippe Briolotti (1) , Francia Razafy (1) , Cédric Duret (1) , Pierre-Alain Rubbo (2) , Francois Helle (3) , Thierry Rème (1) , Marie-Pierre Ripault (4) , Jacques Ducos (2) , Jean-Michel Fabre (4) , Jeanne Ramos (4) , Eve-Isabelle Pécheur (5) , Dominique Larrey (1) , Patrick Maurel (1) , Martine Daujat-Chavanieu (1)

1 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
2 Pathogénèse et contrôle des infections chroniques (PCCI)
3 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
4 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
5 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon

Adult primary human hepatocytes (PHHs) support the complete infection cycle of natural HCV from patients' sera. The molecular details underlying sera infectivity towards these cells remain largely unknown. Therefore, we sought to gain a deeper comprehension of these features in the most physiologically relevant culture system.

Mots clés: CHEMOKINES; CHRONIC HEPATITIS; CYTOKINES; HEPATITIS C; HEPATOCYTE

Domaines: Médecine humaine et pathologie

Claire Gondeau, Philippe Briolotti, Francia Razafy, Cédric Duret, Pierre-Alain Rubbo, et al.. In vitro infection of primary human hepatocytes by HCV-positive sera: insights on a highly relevant model. Gut, 2014, 63 (9), pp.1490-1500. ⟨10.1136/gutjnl-2013-304623⟩. ⟨hal-03082070⟩