Dual time point [18F]FLT-PET for differentiating proliferating tissues vs non-proliferating tissues

Pierre Lovinfosse , Caroline Rousseau , Jean-Yves Pierga , Francis Bouchet , Alexandre Cochet , Jean-Louis Alberini , Sylvie Girault , Pierre Vera , Pierre Olivier , Lionel Uwer , Florent Cachin (1, 2) , Benoit Scarwell , Jérome Lemonnier , Emmanuelle Fourme , Christel Mesleard , Anne-Laure Martin , Franck Lacœuille , Olivier-François Couturier

1 IMoST - Imagerie Moléculaire et Stratégies Théranostiques
2 UNICANCER/CJP - Centre Jean Perrin [Clermont-Ferrand]

For differentiating tumor from inflammation and normal tissues, fluorodeoxyglucose ([18F]FDG) dual time point PET could be helpful. Albeit [18F]FLT is more specific for tumors than [18F]FDG; we explored the role of dual time point [18F]FLT-PET for discriminating benign from malignant tissues.

Mots clés: Breast cancer; FLT; Fluorothymidine; Positron emission tomography

Domaines: Sciences du Vivant [q-bio]

Pierre Lovinfosse, Caroline Rousseau, Jean-Yves Pierga, Francis Bouchet, Alexandre Cochet, et al.. Dual time point [18F]FLT-PET for differentiating proliferating tissues vs non-proliferating tissues. EJNMMI Research, 2019, 9 (1), pp.109. ⟨10.1186/s13550-019-0579-5⟩. ⟨hal-03057101⟩