Efficacy of pentoxifylline–tocopherol–clodronate in mandibular osteoradionecrosis

Alexis Dissard , Nathalie P Dang , Isabelle Barthelemy , Candice Delbet , Mathilde Puechmaille , Arnaud Depeyre , Bruno Pereira , Fanny Martin , Florent Guillemin , Julian Biau (1, 2) , Sonia Mirafzal , Thierry Mom , Laurent Gilain , Nicolas Saroul , Nathalie P. Dang

1 UNICANCER/CJP - Centre Jean Perrin [Clermont-Ferrand]
2 IMoST - Imagerie Moléculaire et Stratégies Théranostiques

PENTOCLO treatment, associating pentoxifylline, tocopherol, and clodronate, resolves radiation-induced fibrosis. The main aim of the present study was to prospectively assess efficacy in mandibular osteoradionecrosis (ORN).

4 Laryngoscope, 130:E559-E566, 2020.

Mots clés: Osteoradionecrosis; clodronate; mandible; pentoxifylline; tocopherol

Domaines: Sciences du Vivant [q-bio]

Alexis Dissard, Nathalie P Dang, Isabelle Barthelemy, Candice Delbet, Mathilde Puechmaille, et al.. Efficacy of pentoxifylline–tocopherol–clodronate in mandibular osteoradionecrosis. Laryngoscope, 2020, 130 (11), pp.E559-E566. ⟨10.1002/lary.28399⟩. ⟨hal-03052619⟩