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Article Dans Une Revue Scientific Reports Année : 2020

Analysis of the StoRM cohort reveals physical activity to be associated with survival in metastatic breast cancer

Lidia Delrieu
Céline Segura-Ferlay
  • Fonction : Auteur
Ellen Blanc
  • Fonction : Auteur
Olivia Febvey-Combes
Christine Friedenreich
Gilles Romieu
  • Fonction : Auteur
William Jacot
Maria Rios
  • Fonction : Auteur
Pierre-Etienne Heudel
Célia Roemer-Becuwe
  • Fonction : Auteur
Christelle Jouannaud
  • Fonction : Auteur
Olivier Tredan
  • Fonction : Auteur
Loïc Chaigneau
  • Fonction : Auteur
Monica Arnedos
  • Fonction : Auteur
Hubert Orfeuvre
  • Fonction : Auteur
Nathalie Quenel-Tueux
  • Fonction : Auteur
Jean-Philippe Jacquin
  • Fonction : Auteur
Jean-Marc Ferrero
Isabelle Moullet
  • Fonction : Auteur
Sophie Abadie-Lacourtoisie
  • Fonction : Auteur
David Cox
  • Fonction : Auteur
Thomas Bachelot

Résumé

Benefits of physical activity are widely demonstrated for early stage cancers but few studies have focused on metastatic disease. The purpose of this study was to determine the impact of physical activity on survival in patients with metastatic breast cancer. We conducted a secondary analysis of the national, multicentric, non-randomized, prospective cohort SNPs to Risk of Metastasis (StoRM) study. The level of physical activity was self-reported at inclusion and divided into three categories of physical activity: light level, moderate level, and vigorous level. Overall, 833 patients (56.2%) completed the physical activity questionnaire at baseline on average physical activity during the previous year: 11.6% had a light level of physical activity, 69.0% achieved moderate levels of physical activity and 19.3% reported vigorous levels of physical activity. After adjustment for confounding, physical activity was not statistically significantly associated with overall survival in the whole population. Subgroup analysis identified that both vigorous and moderate physical activity were associated with statistically significantly improved overall survival compared to light physical activity level only in the HER2 positive subgroup (HR 0.23; 95% CI 0.07-0.70, p = 0.01 and HR 0.38; 95% CI 0.15-0.96, p = 0.04). Physical activity done during the previous year was associated with survival in HER2 positive metastatic breast cancer patients. These results suggest that overall survival in metastatic breast cancer patients could be improved through physical activity which should be considered as a complementary intervention for these individuals. The study showed that moderate/vigorous levels of physical activity were associated with better overall survival, and that these associations remained statistically significant in multivariate analysis in the HER2 positive subgroup. These results have clinical relevance and justify the recommendations for physical activity interventions in metastatic breast cancer.

Dates et versions

hal-03049838 , version 1 (10-12-2020)

Identifiants

Citer

Lidia Delrieu, Emmanuelle Jacquet, Céline Segura-Ferlay, Ellen Blanc, Olivia Febvey-Combes, et al.. Analysis of the StoRM cohort reveals physical activity to be associated with survival in metastatic breast cancer. Scientific Reports, 2020, 10 (1), pp.10757. ⟨10.1038/s41598-020-67431-6⟩. ⟨hal-03049838⟩
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