Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections

Liwen Feng , Sébastien Pomel , Perle Latre de Late (1) , Alexandre Taravaud , Philippe M Loiseau , Louis Maes , Fidelis Cho-Ngwa , Christina A Bulman , Chelsea Fischer , Judy A Sakanari , Peter D Ziniel , David L Williams , Elisabeth Davioud-Charvet (2, 3)

1 IC UM3 (UMR 8104 / U1016) - Institut Cochin
2 CNRS - Centre National de la Recherche Scientifique
3 LIMA - Laboratoire d'innovation moléculaire et applications

Mots clés: anticancer; anti-amoeba; anti-helminth; anti-leishmanial; antiparasitic; anti-trypanosomal; auranofin; glutathione; gold(I) complex; redox equilibrium; thioredoxin

Domaines: Chimie organique; Chimie de coordination; Médicaments

Liwen Feng, Sébastien Pomel, Perle Latre de Late, Alexandre Taravaud, Philippe M Loiseau, et al.. Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections. Molecules, 2020, 25 (21), pp.5075. ⟨10.3390/molecules25215075⟩. ⟨hal-03038691⟩