Palladium-Ruthenium Catalyst Complementarity Strengthens Ortho-Directed C-H Bond Arylation of 2-Arylpyrazines - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ChemCatChem Année : 2021

Palladium-Ruthenium Catalyst Complementarity Strengthens Ortho-Directed C-H Bond Arylation of 2-Arylpyrazines

Résumé

We report the Pd- or Ru-catalyzed C-H bond arylation at the ortho-position of the aryl unit of 2-arylpyrazines. The reaction proceeds with complete regioselectivity using phosphine-free Pd(OAc)(2) or [RuCl2(p-cymene](2) as the catalysts and potassium acetate as an inexpensive base. In all cases, the mono-arylation of 2-arylpyrazines was obtained even with 2,3-diphenylpyrazine. Moreover, the reaction is not sensitive to the pyrazine substitution. By selecting the proper catalytic system, a wide variety of electron-rich and -poor (hetero)aryl bromides, including bromopyridine derivatives, has been successfully employed.

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Chimie
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hal-03035987 , version 1 (02-12-2020)

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Amal Benzai, Fazia Derridj, Henri Doucet, Jean-François Soulé. Palladium-Ruthenium Catalyst Complementarity Strengthens Ortho-Directed C-H Bond Arylation of 2-Arylpyrazines. ChemCatChem, 2021, 13 (1), pp.338-345. ⟨10.1002/cctc.202001338⟩. ⟨hal-03035987⟩
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