Skip to Main content Skip to Navigation
New interface
Journal articles

A network of transcriptional repressors modulates auxin responses.

Abstract : The regulation of signalling capacity, combined with the spatiotemporal distribution of developmental signals themselves, is pivotal in setting developmental responses in both plants and animals1. The hormone auxin is a key signal for plant growth and development that acts through the AUXIN RESPONSE FACTOR (ARF) transcription factors2-4. A subset of these, the conserved class A ARFs5, are transcriptional activators of auxin-responsive target genes that are essential for regulating auxin signalling throughout the plant lifecycle2,3. Although class A ARFs have tissue-specific expression patterns, how their expression is regulated is unknown. Here we show, by investigating chromatin modifications and accessibility, that loci encoding these proteins are constitutively open for transcription. Through yeast one-hybrid screening, we identify the transcriptional regulators of the genes encoding class A ARFs from Arabidopsis thaliana and demonstrate that each gene is controlled by specific sets of transcriptional regulators. Transient transformation assays and expression analyses in mutants reveal that, in planta, the majority of these regulators repress the transcription of genes encoding class A ARFs. These observations support a scenario in which the default configuration of open chromatin enables a network of transcriptional repressors to regulate expression levels of class A ARF proteins and modulate auxin signalling output throughout development.
Document type :
Journal articles
Complete list of metadata
Contributor : Teva Vernoux Connect in order to contact the contributor
Submitted on : Tuesday, November 24, 2020 - 11:12:28 AM
Last modification on : Tuesday, November 29, 2022 - 11:56:13 AM
Long-term archiving on: : Thursday, February 25, 2021 - 7:23:28 PM


Truskina_ main_text_all-rev6_C...
Files produced by the author(s)


Distributed under a Creative Commons Attribution 4.0 International License




Jekaterina Truskina, Jingyi Han, Elina Chrysanthou, Carlos Galvan-Ampudia, Stéphanie Lainé, et al.. A network of transcriptional repressors modulates auxin responses.. Nature, 2021, 589 (7840), pp.116-119. ⟨10.1038/s41586-020-2940-2⟩. ⟨hal-03021204⟩



Record views


Files downloads