Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients

Kazusa Ishii , Marie Pouzolles , Christopher D Chien , Rebecca A Erwin-Cohen , M. Eric Kohler , Haiying Qin , Haiyan Lei , Skyler Kuhn , Amanda K Ombrello , Alina Dulau-Florea , Michael A Eckhaus , Haneen Shalabi , Bonnie Yates , Daniel A Lichtenstein , Valérie S Zimmermann (1) , Taisuke Kondo , Jack F Shern , Howard A Young , Naomi Taylor (1) , Nirali N Shah , Terry J Fry

1 IGMM - Institut de Génétique Moléculaire de Montpellier

Domaines: Sciences du Vivant [q-bio]

Kazusa Ishii, Marie Pouzolles, Christopher D Chien, Rebecca A Erwin-Cohen, M. Eric Kohler, et al.. Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients. The Journal of clinical investigation, 2020, 130 (10), pp.5425 - 5443. ⟨10.1172/JCI130059⟩. ⟨hal-03019525⟩