Amoeboid Swimming Is Propelled by Molecular Paddling in Lymphocytes

Laurene Aoun (1) , Alexander Farutin (2) , Nicolas Garcia-Seyda (1) , Paulin Nègre (1) , Mohd Suhail Rizvi (2) , Sham Tlili (1, 3) , Solene Song (1) , Xuan Luo (1) , Martine Biarnes-Pelicot (1) , Rémi Galland (4) , Jean-Baptiste Sibarita (4) , Alphée Michelot (3) , Claire Hivroz (5) , Salima Rafaï (2) , Marie-Pierre Valignat (1) , Chaouqi Misbah (2) , Olivier Théodoly (1)

1 LAI - Adhésion et Inflammation
2 LIPhy - Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères]
3 IBDML - Institut de Biologie du Développement de Marseille-Luminy
4 IINS - Interdisciplinary Institute for Neuroscience [Bordeaux]
5 Institute Curie

Mammalian cells developed two main migration modes. The slow mesenchymatous mode, like crawling of fibroblasts, relies on maturation of adhesion complexes and actin fibre traction, while the fast amoeboid mode, observed exclusively for leukocytes and cancer cells, is characterized by weak adhesion, highly dynamic cell shapes, and ubiquitous motility on 2D and in 3D solid matrix. In both

Domaines: Physique [physics]; Sciences du Vivant [q-bio]

Laurene Aoun, Alexander Farutin, Nicolas Garcia-Seyda, Paulin Nègre, Mohd Suhail Rizvi, et al.. Amoeboid Swimming Is Propelled by Molecular Paddling in Lymphocytes. Biophysical Journal, 2020, 119 (6), pp.1157-1177. ⟨10.1016/j.bpj.2020.07.033⟩. ⟨hal-03006653⟩