Cyclic cis-1,3-Diamines Derived from Bicyclic Hydrazines: Synthesis and Applications

Claire Fleurisson (1) , Erica Benedetti (1) , Laurent Micouin (1)

1 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques

Cyclic cis-1,3-diamines are versatile building blocks frequently found in natural molecules or biologically active compounds. In comparison with widely studied 1,2-diamines, and despite their chemical similarity, 1,3-diamines have been investigated less intensively probably because of a lack of general synthetic procedures giving access to these compounds with good levels of chemo-, regio-and stereocontrol. In this account we will give a general overview of the biological interest of cyclic cis-1,3-diamines. We will then describe the synthesis and potential applications of these compounds with a particular focus on the work realized in our laboratory.

Domaines: Chimie organique

Claire Fleurisson, Erica Benedetti, Laurent Micouin. Cyclic cis-1,3-Diamines Derived from Bicyclic Hydrazines: Synthesis and Applications. SYNLETT, 2020, ⟨10.1055/s-0040-1707324⟩. ⟨hal-03003668⟩