Multirecombinant Enterovirus A71 Subgenogroup C1 Isolates Associated with Neurologic Disease, France, 2016–2017

Stéphanie Tomba Ngangas (1) , Alexander Lukashev (2) , Gwendoline Jugie (1) , Olga Ivanova (2, 3) , Jean-Michel Mansuy (4) , Catherine Mengelle (4) , Jacques Izopet (4) , Anne-Sophie L’honneur (5) , Flore Rozenberg (5) , David Leyssene (6) , Denise Hecquet (7) , Stéphanie Marque-Juillet (8) , David Boutolleau (5) , Sonia Burrel (5) , Hélène Peigue-Lafeuille (1, 9) , Christine Archimbaud (1, 9) , Kimberley Benschop (10) , Cécile Henquell (1, 9) , Audrey Mirand (1, 9) , Jean-Luc Bailly (1, 9)

1 UCA [2017-2020] - Université Clermont Auvergne [2017-2020]
2 Sechenov First Moscow State Medical University
3 RAS - the Russian Academy of Sciences [Moscow, Russia]
4 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
5 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
6 CHCB - Centre Hospitalier de la Côte Basque
7 CHU Amiens-Picardie
8 CHV - Centre Hospitalier de Versailles André Mignot
9 CHU Clermont-Ferrand
10 RIVM - National Institute for Public Health and the Environment [Bilthoven]

In 2016, an upsurge of neurologic disease associated with infection with multirecombinant enterovirus A71 subgenogroup C1 lineage viruses was reported in France. These viruses emerged in the 2000s; 1 recombinant is widespread. This virus lineage has the potential to be associated with a long-term risk for severe disease among children.

Mots clés: 3Dpol; 5′ UTR; C1 subgenogroup; C1v2015 lineage; EV-A71; France; children; coxsackievirus; enterovirus; enterovirus infection; epidemiologic monitoring; genetic recombination; genomic region P1; most recent common ancestor; neurologic disease; neurologic manifestations; viruses; whole-genome sequencing

Domaines: Virologie; Biodiversité et Ecologie; Environnement et Société; Milieux et Changements globaux; Ingénierie de l'environnement

Stéphanie Tomba Ngangas, Alexander Lukashev, Gwendoline Jugie, Olga Ivanova, Jean-Michel Mansuy, et al.. Multirecombinant Enterovirus A71 Subgenogroup C1 Isolates Associated with Neurologic Disease, France, 2016–2017. Emerging Infectious Diseases, 2019, 25 (6), pp.1204-1208. ⟨10.3201/eid2506.181460⟩. ⟨hal-02998667⟩