Mn(II)-based MRI contrast agent candidate for vascular imaging

Ferenc K Kalman (1) , Viktória Nagy , Balázs Váradi , Zoltán Garda , Enikő Molnár , György Trencsényi , János Kiss , Sandra Même (2) , William Même (2) , Eva Tóth (2) , Gyula Tircsó

1 University of Debrecen Egyetem [Debrecen]
2 CBM - Centre de biophysique moléculaire

Toxicity concerns related to Gd(III)-based magnetic resonance imaging (MRI) agents prompted an intensive research toward their replacement by complexes of essential metal ions, like Mn(II). Here, we report a macrocyclic chelate, [Mn(PC2A-BP)], which possesses high thermodynamic stability (log K MnL = 14.86 and pMn=8.35) and kinetic inertness (t 1/2 pH=7.4 = 286.2 h) as well as as remarkable relaxivity (r 1p = 23.5 mM −1 s −1 , 0.49 T, 37°C) in the presence of human serum albumin, allowing a significant MRI signal intensity increase in the vasculature even at low dose (25 μmol/kg) of the complex.

Domaines: Imagerie

Ferenc K Kalman, Viktória Nagy, Balázs Váradi, Zoltán Garda, Enikő Molnár, et al.. Mn(II)-based MRI contrast agent candidate for vascular imaging. Journal of Medicinal Chemistry, 2020, 63 (11), pp.6057-6065. ⟨10.1021/acs.jmedchem.0c00197⟩. ⟨hal-02996069⟩